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Citywide STI Screening Guidelines
Guidelines for screening based on a patient's age and sexual practices. Updated 2025.
City Clinic STI Protocols
Protocols for STI treatment and management. Updated 2023.
These are our most-requested resources for providers.
Created by City Clinic.
All guidelines, protocols, and toolkits
We provide materials and resources to support your sexual health clinical practice. We also provide key resources from state and federal health agencies.
Resources include guides, guidelines, protocols, and patient education and instructions.
STIs
Screening and treatment protocols for STIs
SF resources
San Francisco Citywide STI Screening Guidelines, January 2025 (PDF)
Guidelines for screening based on a patient's age and sexual practices
San Francisco City Clinic STI Protocols, 2023 (PDF)
Protocols for STI treatment and management
Ureaplasma urealyticum provider FAQ (PDF)
Guidance for screening, testing, and treatment; how to interpret positive test results in asymptomatic patients; and partner management
National resources
CDC STI Treatment Guidelines, 2021
Find supplemental materials to the CDC guidelines below.
Additional syphilis resources
Syphilis resources for SF providers
Includes Bicillin shortage tools; tools for screening, evaluating, and staging syphilis; congenital syphilis prevention; and patient education tools
Management of gonorrhea
State resources
- Clinical Guidelines for Gonorrhea Treatment and Management of Suspected Treatment Failure (PDF)
- Disseminated Gonorrhea Infections: FAQ for Health Care Providers (PDF)
- Antibiotic-Resistant Gonorrhea (ARGC) Quicksheet (PDF)
Find more resources from the California Department of Public Health.
Expedited partner therapy
Expedited partner therapy resources for California providers
Hosted by Essential Access, a partner of the California Department of Public Health
Specimen self-collection for STI testing
Patient education tools for STIs
STI fact sheets and more
Browse the STI and HIV educational tools we use with our patients. Includes fact sheets for each STI.
Doxy-PEP
Prescribing doxy-PEP
SF resources
Doxy-PEP prescribing guide for San Francisco providers (PDF)
Guidance on doxy-PEP eligibility, dosing and prescribing, monitoring, and counseling messages
Health Update: Updated Recommendations for Prescribing Doxycycline Post-Exposure Prophylaxis (Doxy-PEP) (PDF)
Published September 12, 2024
State resources
California Department of Public Health Doxy-PEP Recommendations (PDF)
Published April 28, 2023
National resources
CDC Guidelines on the Use of Doxy-PEP, 2024 (PDF)
Current version on CDC.gov
Patient education tools for doxy-PEP
Here are our doxy-PEP fact sheets:
- About doxy-PEP (PDF)
- "Doxy-PEP dosing instructions" (PDF)
You can also find these on our doxy-PEP page.
PrEP
Prescribing PrEP
SF resources
"Ask about PrEP": A guide for providers (PDF)
Guide to prescribing PrEP for San Francisco providers
Prescribing Injectable Cabotegravir PrEP Pocket Card (PDF)
Guide to prescribing injectable cabotegravir for PrEP in pocket card format
National resources
CDC PrEP Guidelines, 2021 Update (PDF)
Version saved before January 2025 (PDF)
CDC PrEP Guidelines - Clinical Providers’ Supplement, 2021 Update (PDF)
Version saved before January 2025 (PDF)
Clinical Recommendation for the Use of Injectable Lenacapavir as PrEP (2025) (PDF)
The CDC recommends injectable lenacapavir as an option for PrEP, and provides clinical guidance.
CDC guide: What is injectable HIV PrEP? (PDF)
Guide to prescribing injectable cabotegravir for PrEP
Phone consultation on PrEP
The National Clinician Consultation Center provides free phone consultation on management of PrEP.
Coverage options for injectable PrEP
SF resources
Apretude Insurance Flowsheet (PDF)
Guide to insurance coverage of Apretude (cabotegravir) for PrEP
Yeztugo Insurance Flowsheet (PDF)
Guide to insurance coverage of Yeztugo (lenacapavir) for PrEP
For frontline workers
SF resource
The frontline worker's role in LAI PrEP team-based care (PDF)
How non-clinical staff can support clients in accessing injectable PrEP and ART
Patient education tools for PrEP
Our PrEP page provides education about PrEP.
You can also use these PrEP fact sheets:
Created by City Clinic:
- PrEP Basics (PDF)
- Injectable PrEP Basics (PDF)
- Compare types of PrEP (PDF)
Created by the California Department of Public Health:
- 2-1-1 PrEP (PDF)
PEP
Prescribing PEP
National resource
CDC PEP Guidelines for Nonoccupational Exposure to HIV, 2025 (PDF)
Current version on CDC.gov
Phone consultation on PEP
The National Clinician Consultation Center provides free phone consultation on management of PEP.
Patient education tools for PEP
Our PEP page provides education about PEP.
HIV treatment
Prescribing HIV treatment
SF resource
Rapid ART: Immediate ART initiation at HIV diagnosis and re-engagement in care (PDF)
How to offer immediate ART initiation, and implement it in your practice
National resource
Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV
Current version on HIV.gov
Patient education tools for HIV treatment
- Our HIV care page provides education about HIV treatment.
- You can also use our U=U fact sheet: U=U Basics (Undetectable = Untransmittable)

More sexual health resources for providers
Learn about disease reporting in SF, find clinical guidelines and toolkits, sign up for health alerts, and see epidemiological data and reports.See more resources for providersAbout
San Francisco City Clinic is a trusted source for sexual health services and information, known for our experienced professionals and our commitment to delivering compassionate, high-quality care for over 100 years.
Our mission is to improve our community’s sexual health by preventing, diagnosing, and treating sexually transmitted infections (STIs) and HIV, and preventing unintended pregnancy.
Find all City Clinic services and information
Contact information
Address
San Francisco, CA 94102
Monday, Wednesday, Friday
8:00 am to 4:00 pm
Tuesday
1:00 pm to 6:00 pm
Thursday
8:00 am to 11:00 am
1:00 pm to 4:00 pm
Walk-ins may end earlier for some services.
We are closed weekends and holidays.
Phone
Additional info
Medical leadership
Oliver Bacon, MD, MPH: 628-217-6658
Medical Director, City Clinic
San Francisco Department of Public Health
Franco Chevalier, MD, MPH: 628-217-6605
Deputy Medical Director, City Clinic
San Francisco Department of Public Health
Stephanie Cohen, MD, MPH: 628-217-6674
Director, STI/HIV Branch
Population Health Division
San Francisco Department of Public Health
Julia Janssen, MD: 628-217-6074
Deputy Director, STI/HIV Branch
Population Health Division
San Francisco Department of Public Health