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City Clinic clinical guidelines and toolkits

San Francisco City Clinic
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We are here to help: 628-217-6677

Most popular


Citywide STI Screening Guidelines

Guidelines for screening based on a patient's age and sexual practices. Updated 2025.


City Clinic STI Protocols

Protocols for STI treatment and management. Updated 2023.

These are our most-requested resources for providers.

Created by City Clinic.

All guidelines, protocols, and toolkits

We provide materials and resources to support your sexual health clinical practice. We also provide key resources from state and federal health agencies.

Resources include guides, guidelines, protocols, and patient education and instructions.

STIs

Screening and treatment protocols for STIs

SF resources


San Francisco Citywide STI Screening Guidelines, January 2025 (PDF)

Guidelines for screening based on a patient's age and sexual practices

San Francisco City Clinic STI Protocols, 2023 (PDF)

Protocols for STI treatment and management

Ureaplasma urealyticum provider FAQ (PDF)

Guidance for screening, testing, and treatment; how to interpret positive test results in asymptomatic patients; and partner management

National resources


CDC STI Treatment Guidelines, 2021

Find supplemental materials to the CDC guidelines below.

Additional syphilis resources


Syphilis resources for SF providers

Includes Bicillin shortage tools; tools for screening, evaluating, and staging syphilis; congenital syphilis prevention; and patient education tools

Management of gonorrhea

Expedited partner therapy


Expedited partner therapy resources for California providers

Hosted by Essential Access, a partner of the California Department of Public Health

Specimen self-collection for STI testing


Printable instructions for patients


Video instructions for patients

Patient education tools for STIs


STI fact sheets and more

Browse the STI and HIV educational tools we use with our patients. Includes fact sheets for each STI.

Doxy-PEP

Prescribing doxy-PEP

SF resources

Doxy-PEP prescribing guide for San Francisco providers (PDF)

Guidance on doxy-PEP eligibility, dosing and prescribing, monitoring, and counseling messages

Health Update: Updated Recommendations for Prescribing Doxycycline Post-Exposure Prophylaxis (Doxy-PEP) (PDF)

Published September 12, 2024


State resources

California Department of Public Health Doxy-PEP Recommendations (PDF)

Published April 28, 2023

National resources

CDC Guidelines on the Use of Doxy-PEP, 2024 (PDF)

Current version on CDC.gov

Patient education tools for doxy-PEP

Here are our doxy-PEP fact sheets:

You can also find these on our doxy-PEP page.

PrEP

Prescribing PrEP

SF resources


"Ask about PrEP": A guide for providers (PDF)

Guide to prescribing PrEP for San Francisco providers

Prescribing Injectable Cabotegravir PrEP Pocket Card (PDF)

Guide to prescribing injectable cabotegravir for PrEP in pocket card format


National resources


CDC PrEP Guidelines, 2021 Update (PDF)

Version saved before January 2025 (PDF)


CDC PrEP Guidelines - Clinical Providers’ Supplement, 2021 Update (PDF)

Version saved before January 2025 (PDF)

Clinical Recommendation for the Use of Injectable Lenacapavir as PrEP (2025) (PDF)

The CDC recommends injectable lenacapavir as an option for PrEP, and provides clinical guidance.

CDC guide: What is injectable HIV PrEP? (PDF)

Guide to prescribing injectable cabotegravir for PrEP



Phone consultation on PrEP

The National Clinician Consultation Center provides free phone consultation on management of PrEP.

Coverage options for injectable PrEP

SF resources


Apretude Insurance Flowsheet (PDF)

Guide to insurance coverage of Apretude (cabotegravir) for PrEP

Yeztugo Insurance Flowsheet (PDF)

Guide to insurance coverage of Yeztugo (lenacapavir) for PrEP

For frontline workers

SF resource

The frontline worker's role in LAI PrEP team-based care (PDF)

How non-clinical staff can support clients in accessing injectable PrEP and ART

Patient education tools for PrEP

Our PrEP page provides education about PrEP.

You can also use these PrEP fact sheets:

Created by City Clinic:

Created by the California Department of Public Health:

PEP

Prescribing PEP

National resource


CDC PEP Guidelines for Nonoccupational Exposure to HIV, 2025 (PDF)

Current version on CDC.gov

Phone consultation on PEP

The National Clinician Consultation Center provides free phone consultation on management of PEP.

Patient education tools for PEP

Our PEP page provides education about PEP.

HIV treatment

Prescribing HIV treatment

SF resource

Rapid ART: Immediate ART initiation at HIV diagnosis and re-engagement in care (PDF)

How to offer immediate ART initiation, and implement it in your practice


National resource

Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV

Current version on HIV.gov

Patient education tools for HIV treatment

More sexual health resources for providers

Learn about disease reporting in SF, find clinical guidelines and toolkits, sign up for health alerts, and see epidemiological data and reports.See more resources for providers

About

San Francisco City Clinic is a trusted source for sexual health services and information, known for our experienced professionals and our commitment to delivering compassionate, high-quality care for over 100 years.

Our mission is to improve our community’s sexual health by preventing, diagnosing, and treating sexually transmitted infections (STIs) and HIV, and preventing unintended pregnancy.

Find all City Clinic services and information

Contact information

Address

San Francisco City Clinic356 7th Street
San Francisco, CA 94102
Get directions

Monday, Wednesday, Friday
8:00 am to 4:00 pm

Tuesday
1:00 pm to 6:00 pm

Thursday
8:00 am to 11:00 am
1:00 pm to 4:00 pm

Walk-ins may end earlier for some services.

We are closed weekends and holidays.

Phone

City Clinic main phone number628-217-6600

Additional info

Medical leadership

Oliver Bacon, MD, MPH: 628-217-6658
Medical Director, City Clinic
San Francisco Department of Public Health

Franco Chevalier, MD, MPH: 628-217-6605
Deputy Medical Director, City Clinic
San Francisco Department of Public Health

Stephanie Cohen, MD, MPH: 628-217-6674
Director, STI/HIV Branch
Population Health Division
San Francisco Department of Public Health

Julia Janssen, MD: 628-217-6074
Deputy Director, STI/HIV Branch
Population Health Division
San Francisco Department of Public Health